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135065-47-3

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135065-47-3 Usage

Classification

Flavonoid derivative of chromenone

Properties

Antioxidant and anti-inflammatory

Uses

Potential therapeutic applications, research tool in biological systems, building block for synthesis of biologically active compounds
Potential for interaction with various biological targets and interest for pharmaceutical development

Check Digit Verification of cas no

The CAS Registry Mumber 135065-47-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,5,0,6 and 5 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 135065-47:
(8*1)+(7*3)+(6*5)+(5*0)+(4*6)+(3*5)+(2*4)+(1*7)=113
113 % 10 = 3
So 135065-47-3 is a valid CAS Registry Number.

135065-47-3Downstream Products

135065-47-3Relevant articles and documents

Novel C7-substituted coumarins as selective monoamine oxidase inhibitors: Discovery, synthesis and theoretical simulation

Wang, Dong,Hong, Ren-Yuan,Guo, Mengyao,Liu, Yi,Chen, Nianhang,Li, Xun,Kong, De-Xin

, (2019)

There is a continued need to develop new selective human monoamine oxidase (hMAO) inhibitors that could be beneficial for the treatment of neurological diseases. However, hMAOs are closely related with high sequence identity and structural similarity, which hinders the development of selective MAO inhibitors. “Three-Dimensional Biologically Relevant Spectrum (BRS-3D)” method developed by our group has demonstrated its effectiveness in subtype selectivity studies of receptor and enzyme ligands. Here, we report a series of novel C7-substituted coumarins, either synthesized or commercially purchased, which were identified as selective hMAO inhibitors. Most of the compounds demonstrated strong activities with IC50 values (half-inhibitory concentration) ranging from sub-micromolar to nanomolar. Compounds, FR1 and SP1, were identified as the most selective hMAO-A inhibitors, with IC50 values of 1.5 nM (selectivity index (SI) 50 of 18 nM and 15 nM (SI > 2.74 and SI > 2.82). Docking calculations and molecular dynamic simulations were performed to elucidate the selectivity preference and SAR profiles.

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