1350660-72-8

Basic information

• Product Name: 5-(3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl)pyrimidine-2,4(1H,3H)-dione
• Synonyms: 5-(3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl)pyrimidine-2,4(1H,3H)-dione
• CAS NO: 1350660-72-8
• Molecular Weight: 290.666
• Mol File: 1350660-72-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-(3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl)pyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl)pyrimidine-2,4(1H,3H)-dione(1350660-72-8)
• EPA Substance Registry System: 5-(3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl)pyrimidine-2,4(1H,3H)-dione(1350660-72-8)

Safety Data

• Hazardous Substances Data: 1350660-72-8(Hazardous Substances Data)

Upstream product

• 3848-36-0 4-chlorobenzaldoxime 
• 4425-56-3 5-cyanouracil 
• 28123-63-9 4-chlorobenzohydroximoyl chloride 

Relevant articles and documents

Synthesis of 5-hetaryluracil derivatives via 1,3-dipolar cycloaddition reaction

1,3-Dipolar cycloaddition is a convenient method for construction of various heterocyclic systems. We applied this method for the synthesis 5-hetaryluracil derivatives where substituted uracils played the role of 1,3-dipoles or dipolarophiles. Treatment of the nitrile oxide derived from 5-formyluracil and substituted alkenes gave the appropriate 5-(4,5-dihydroisoxazol-3-yl)pyrimidine-2,4(1H,3H)-diones, which by oxidation with N-bromosuccinimide were transformed into appropriate 5-(isoxazol-3-yl)uracils. When 5-cyanouracil was used as a dipolarophile in the reaction with nitrile oxides, generated from aromatic aldoximes, several 5-(1,2,4-oxadiazol-5-yl)uracils were obtained. An alternative reaction of 5-formyluracil with an excess of nitriles in the presence of cerium ammonium nitrate as an oxidant gave 1,2,4-oxadiazol-3-yl derivatives in moderate yields. (Chemical Equation Presented).