135067-76-4

Upstream product

• 1666-13-3 diphenyl diselenide 
• 54503-61-6 2',3'-O-isopropylidene-5-bromouridine 
• 5707-04-0 Phenylselenyl chloride 
• 19556-62-8 6,5'-anhydro-1-(2,3-O-isopropylidene-β-D-ribofuranosyl)barbituric acid 
• 362-43-6 2',3'-O-isopropylideneuridine 

Relevant academic research and scientific papers

Synthesis of 5-arylthiouridines via electrophilic substitution of 5- bromouridines with diaryl disulfides

Novel synthetic method of 5-arylthiouridine derivatives is described. Treatment of 5-bromo-2',3'-O-isopropylideneuridine (1a) with diaryl disulfides in the presence of sodium hydride at ambient temperature gave the 5-arylthiouridines (2) in moderate yields. The present method is devised by virtue of a combination of efficient participation of the 5'-hydroxy group onto the uracil ring and the electrophilic nature of diaryl disulfide, which was applied to the synthesis of 5-arylthio-1-β-D-arabinofuranosyluracils (8).

Direct regioselective arylsulfenylation and arylselenenylation at 5-position of uracils mediated by silver reagents

Electrophilic additions of phenylsulfenyl chloride or phenylselenenyl chloride to a carbon-carbon double bond of C-5,6 region uracils in the presence of silver reagents such as Ag2O, AgBF4, or AgOCOCF3 directly gave the co