1350705-77-9

Upstream product

• 1350705-72-4 N-((1R,2R)-1-((tert-butyldimethylsilyl)oxy)-1-(4-(2-cyanoethoxy)phenyl)-3-hydroxy propan-2-yl)-2-(1H-indol-3-yl)-2-oxoacetamide 
• 22980-09-2 indolyl-3-glyoxylyl chloride 
• 123-08-0 4-hydroxy-benzaldehyde 
• 104315-07-3 (E)-ethyl 3-(4-(benzyloxy)phenyl)acrylate 
• 1350705-70-2 tert-butyl (1R,2R)-1-(tert-butyldimethylsilyloxy)-1-(4-(2-cyanoethoxy)phenyl)-3-hydroxypropan-2-ylcarbamate 
• 1350705-83-7 ethyl (2S,3R)-2-((tert-butoxycarbonyl)amino)-3-((tert-butyldimethylsilyl)oxy)-3-(4-(2-cyanoethoxy)phenyl)propanoate 
• 1350705-69-9 ethyl (2S,3R)-2-((tert-butoxycarbonyl)amino)-3-((tert-butyldimethylsilyl)oxy)-3-(4-hydroxyphenyl)propanoate 
• 1350705-81-5 (2S,3R)-ethyl 3-(4-(benzyloxy)phenyl)-2-((tert-butoxycarbonyl)amino)-3-((tert-butyldimethylsilyl)oxy)propanoate 
• 1350705-68-8 ethyl (2S,3R)-3-(4-(benzyloxy)phenyl)-2-((tert-butoxycarbonyl)amino)-3-hydroxypropanoate 
• 1350705-71-3 C₁₈H₃₀N₂O₃Si 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 120-72-9 indole 

Downstream Products

• 1350930-48-1 oxazinin-5 

Relevant academic research and scientific papers

Asymmetric first total syntheses and assignment of absolute configuration of oxazinin-5, oxazinin-6 and preoxazinin-7

Asymmetric first total syntheses of the unprecedented toxins oxazinin-5, oxazinin-6 and preoxazinin-7 have been achieved from a common key intermediate 18, derived from a regiocontrolled Sharpless asymmetric aminohydroxylation and oxa-Michael reaction, which in addition to confirming the structure also established the absolute configuration of the natural products. On the way an expeditious synthesis of a metabolite bursatellin was completed in 8 steps. The Royal Society of Chemistry 2011.