135072-15-0

Basic information

• Product Name: 4-BENZYL-2-MORPHOLINECARBOXYLIC ACID HYDROCHLORIDE
• Synonyms: BENZYL(N-)-MORPHOLINE-2-CARBOXYLIC ACID HCL;4-BENZYL-2-MORPHOLINECARBOXYLIC ACID HYDROCHLORIDE;4-BENZYL-MORPHOLINE-2-CARBOXYLIC ACID HYDROCHLORIDE;4-Benzyl-2-morpholinecarboxylicacidHCl;4-Benzyl-2-morpholinecarboxylic acid hydrochloride, 90+%;4-Benzyl-2-carboxymorpholine hydrochloride;2-Morpholinecarboxylic acid, 4-(phenylmethyl)-, hydrochloride
• CAS NO: 135072-15-0
• Molecular Formula: C₁₂H₁₅NO₃*ClH
• Molecular Weight: 257.71
• Product Categories: pharmacetical;Carboxylic Acids;Morpholines & Thiomorpholines;Carboxylic Acids;Morpholines & Thiomorpholines
• Mol File: 135072-15-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 244 °C
• Boiling Point: 372.7 °C at 760 mmHg
• Flash Point: 179.2 °C
• Appearance: /
• Density: 1.235g/cm³
• Vapor Pressure: 3.25E-06mmHg at 25°C
• Refractive Index: 1.571
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-BENZYL-2-MORPHOLINECARBOXYLIC ACID HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BENZYL-2-MORPHOLINECARBOXYLIC ACID HYDROCHLORIDE(135072-15-0)
• EPA Substance Registry System: 4-BENZYL-2-MORPHOLINECARBOXYLIC ACID HYDROCHLORIDE(135072-15-0)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36/37/39
• HazardClass: 6.1
• Hazardous Substances Data: 135072-15-0(Hazardous Substances Data)

Usage

General Description

4-BENZYL-2-MORPHOLINECARBOXYLIC ACID HYDROCHLORIDE is a chemical compound that consists of a benzyl group and a morpholine ring attached to a carboxylic acid group, with a hydrochloride salt form. 4-BENZYL-2-MORPHOLINECARBOXYLIC ACID HYDROCHLORIDE has important applications in the pharmaceutical industry, particularly as a building block for the synthesis of various drugs and pharmaceutical agents. It has also been studied for its potential use in the treatment of mood disorders and other psychiatric conditions. Additionally, it may have potential applications in organic synthesis and as a reagent in chemical reactions. Overall, 4-BENZYL-2-MORPHOLINECARBOXYLIC ACID HYDROCHLORIDE is a versatile chemical compound with diverse uses and potential therapeutic benefits.

InChI:InChI=1/C12H15NO3/c14-12(15)11-9-13(6-7-16-11)8-10-4-2-1-3-5-10/h1-5,11H,6-9H2,(H,14,15)

Upstream product

• 104-63-2 N-Benzylethanolamine 
• 147767-51-9 4-benzyl-2-cyanomorpholine 

Downstream Products

• 1401233-77-9 N-cyclohexylmorpholine-2-carboxamide hydrochloride 
• 1030837-49-0 (S)-4-benzyl-morpholine-2-carboxylic acid 
• 1401233-92-8 (R)-4-benzylmorpholine-2-carboxyester 
• 1401233-93-9 (R)-4-benzylmorpholine-2-carboxylic acid hydrochloride 

Relevant articles and documents

A COMPOUND FOR INHIBITING HUMAN 11-β-HYDROXY STEROID DEHYDROGENASE TYPE 1, AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to a novel compound, or a stereoisomer, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for human-11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) comprising the same. The invention provides a compound, which has excellent activity and solubility and is more efficiently formulated and delivered, and a pharmaceutical composition for human-11-beta-hydroxysteroid dehydrogenase type 1 comprising the same.

Practical synthesis of chiral 2-morpholine: (4-Benzylmorpholin-2-(s)-yl)- (tetrahydropyran-4-yl) Methanone mesylate, a useful pharmaceutical intermediate

A commercial synthesis was developed for the production of (4-benzylmorpholin-2-(S)-yl)-(tetrahydropyran-4-yl) methanone mesylate, la, a key starting material for a phase 2, new investigational drug candidate at Eli Lilly and Company. The target compound was produced in the clinical pilot plant by the combination of two key steps: resolution of a morpholine amide intermediate to install the S-morpholino stereocenter in 35% yield and a high-yielding (89%) Grignard reaction to generate the title compound la, isolated as a mesylate salt. The Grignard reaction was found to proceed optimally when using a combination of I2 and DIBAL-H for the initiation. In addition, the Grignard reagent formation was monitored by ReactMax calorimetry, and proof-of-concept studies were completed, demonstrating that the Grignard step could potentially be run as a continuous process with magnesium recycling.