135072-15-0

Usage

Uses

Used in Pharmaceutical Industry:
4-BENZYL-2-MORPHOLINECARBOXYLIC ACID HYDROCHLORIDE is used as a building block for the synthesis of various drugs and pharmaceutical agents, leveraging its structural components to create a diverse range of therapeutic compounds.
Used in Mood Disorder Treatment:
In the field of psychiatry, 4-BENZYL-2-MORPHOLINECARBOXYLIC ACID HYDROCHLORIDE is studied for its potential use in the treatment of mood disorders, offering a new avenue for the development of psychiatric medications.
Used in Organic Synthesis:
4-BENZYL-2-MORPHOLINECARBOXYLIC ACID HYDROCHLORIDE is utilized in organic synthesis, contributing to the creation of complex organic molecules for various applications, including pharmaceuticals, materials, and specialty chemicals.
Used as a Chemical Reaction Reagent:
4-BENZYL-2-MORPHOLINECARBOXYLIC ACID HYDROCHLORIDE also serves as a reagent in chemical reactions, facilitating specific transformations and processes that are essential in the synthesis of target molecules, thereby expanding its applications across different areas of chemistry.

InChI:InChI=1/C12H15NO3/c14-12(15)11-9-13(6-7-16-11)8-10-4-2-1-3-5-10/h1-5,11H,6-9H2,(H,14,15)

Upstream product

• 147767-51-9 4-benzyl-2-cyanomorpholine 
• 104-63-2 N-Benzylethanolamine 

Downstream Products

• 1131220-55-7 4-benzyl-2-(3-phenyl-1,2,4-oxadiazol-5-yl)morpholine 
• 852237-30-0 (4-benzylmorpholin-2-yl)(morpholino)methanone hydrochloride 
• 1401233-77-9 N-cyclohexylmorpholine-2-carboxamide hydrochloride 
• 1030837-49-0 (S)-4-benzyl-morpholine-2-carboxylic acid 
• 1401233-92-8 (R)-4-benzylmorpholine-2-carboxyester 
• 1401233-93-9 (R)-4-benzylmorpholine-2-carboxylic acid hydrochloride 

Relevant academic research and scientific papers

A COMPOUND FOR INHIBITING HUMAN 11-β-HYDROXY STEROID DEHYDROGENASE TYPE 1, AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to a novel compound, or a stereoisomer, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for human-11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) comprising the same. The invention provides a compound, which has excellent activity and solubility and is more efficiently formulated and delivered, and a pharmaceutical composition for human-11-beta-hydroxysteroid dehydrogenase type 1 comprising the same.

CHEMICAL COMPOUNDS

The invention is directed to 6-(4-pyι?midinyl)-1 H-indazole derivatives. Specifically, the invention is directed to compounds according to Formula (I) wherein R1 - R4 are defined herein. The compounds of the invention are inhibitors of PDK1 and can be useful in the treatment of immune and metabolic diseases and disorders characterized by constitutively activated ACG kinases such as cancer and more specifically cancers of the breast, colon, and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PDK1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Practical synthesis of chiral 2-morpholine: (4-Benzylmorpholin-2-(s)-yl)- (tetrahydropyran-4-yl) Methanone mesylate, a useful pharmaceutical intermediate

A commercial synthesis was developed for the production of (4-benzylmorpholin-2-(S)-yl)-(tetrahydropyran-4-yl) methanone mesylate, la, a key starting material for a phase 2, new investigational drug candidate at Eli Lilly and Company. The target compound was produced in the clinical pilot plant by the combination of two key steps: resolution of a morpholine amide intermediate to install the S-morpholino stereocenter in 35% yield and a high-yielding (89%) Grignard reaction to generate the title compound la, isolated as a mesylate salt. The Grignard reaction was found to proceed optimally when using a combination of I2 and DIBAL-H for the initiation. In addition, the Grignard reagent formation was monitored by ReactMax calorimetry, and proof-of-concept studies were completed, demonstrating that the Grignard step could potentially be run as a continuous process with magnesium recycling.

MORPHOLINE DERIVATIVES AS NOREPINEPHRINE REUPTAKE INHIBITORS

Compounds of the general formula (I) are inhibitors of the reuptake of norepinephrine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system.