135072-32-1

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl4-benzylmorpholine-2-carboxylate is used as an intermediate for the synthesis of 5-HT4 receptor agonists. These agonists are essential in the development of medications targeting gastrointestinal disorders, as they help regulate the motility of the gastrointestinal tract and enhance the overall digestive process.
Additionally, Ethyl4-benzylmorpholine-2-carboxylate is used as an intermediate for the preparation of gastric motility stimulants. These stimulants are vital in treating conditions such as gastroparesis, where the stomach's ability to empty its contents is impaired, leading to various symptoms like nausea, vomiting, and abdominal pain.

InChI:InChI=1/C14H19NO3/c1-2-17-14(16)13-11-15(8-9-18-13)10-12-6-4-3-5-7-12/h3-7,13H,2,8-11H2,1H3

Upstream product

• 104-63-2 N-Benzylethanolamine 
• 1030837-46-7 3-(benzyl(2-hydroxyethyl)amino)-2-chloro-propanenitrile 
• 64-17-5 ethanol 
• 147767-51-9 4-benzyl-2-cyanomorpholine 

Downstream Products

• 135782-25-1 2-morpholinecarboxylic acid ethyl ester 
• 768371-16-0 4-(tert-butyl) 2-ethyl morpholine-2,4-dicarboxylate 
• 852237-31-1 (S)-4-benzyl-morpholine-2-carboxylic acid ethyl ester 
• 852237-12-8 2-(4-benzyl-morpholin-2-yl)-1,3-bis-(2-methoxy-phenyl)-propan-2-ol 
• 941710-14-1 (-)-ethyl (2R)-4-benzylmorpholine-2-carboxylate 
• 1111640-52-8 ethyl morpholine-2-carboxylate trifluoroacetate 
• 852237-32-2 4-benzyl-N-methoxy-N-methylmorpholine-2-carboxamide 

Relevant academic research and scientific papers

MORPHOLINE DERIVATIVES AS NOREPINEPHRINE REUPTAKE INHIBITORS

Compounds of the general formula (I) are inhibitors of the reuptake of norepinephrine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system.

TREATMENT OF HOT FLASHES, IMPULSE CONTROL DISORDERS AND PERSONALITY CHANGE DUE TO A GENERAL MEDICAL CONDITION

Selective norepinephrine reuptake inhibitors are useful for the prevention or treatment of hot flashes, vasomotor symptoms, impulse control disorders or personality change due to a general medical condition.

Substituted Benzamides with Conformationally Restricted Side Chains. 5. Azabicyclo Derivatives as 5-HT4 Receptor Agonists and Gastric Motility Stimulants

The syntheses of benzamides containing azabicyclo side chains and their 5-HT4 receptor agonist and 5-HT3 receptor antagonist properties are described.These compounds were designed to mimic higher energy conformations of quinol

The synthesis of 2-morpholine carboxylic acid derivatives and their elaboration to 1-aza-4-oxabicyclo[3.3.1]nonan-6-one

Two syntheses of novel 2-morpholine carboxylic acid derivatives are described. The esters were converted into 1-aza-4-oxabicyclo[3.3.1]nonan-6-one, the first example of this ring system, which was further elaborated to the ortho-methoxy benzamide derivative (2).