1350761-25-9Relevant articles and documents
Optimization of Preclinical Metabolism for Somatostatin Receptor Subtype 5-Selective Antagonists
Liu, Weiguo,Hussain, Zahid,Zang, Yi,Sweis, Ramzi F.,Romero, F. Anthony,Finke, Paul E.,Moningka, Remond,Bao, Jianming,Plotkin, Michael A.,Shang, Jin,Dingley, Karen H.,Salituro, Gino,Murphy, Beth Ann,Howard, Andrew D.,Ujjainwalla, Feroze,Wood, Harold B.,Duffy, Joseph L.
supporting information, p. 1088 - 1093 (2018/10/24)
A series of structurally diverse azaspirodecanone and spirooxazolidinone analogues were designed and synthesized as potent and selective somatostatin receptor subtype 5 (SSTR5) antagonists. Four optimized compounds each representing a subseries showed imp
SPIRO ISOXAZOLINE COMPOUNDS AS SSTR5 ANTAGONISTS
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Page/Page column 99; 100, (2011/12/04)
Substituted spirocyclic amines of structural formula (I) are selective antagonists of the somatostatin subtype receptor 5 (SSTR5) and are useful for the treatment, control or prevention of disorders responsive to antagonism of SSTR5, such as Type 2 diabetes, insulin resistance, lipid disorders, obesity, atherosclerosis, Metabolic Syndrome, depression, and anxiety.