Cas 1350765-15-9,4-[4-Chloro-2-(4-chloro-3-trifluoroMethyl-benzenesulfonylaMino)-phenoxy]-3-Methoxy-N-(2-piperidin-1-yl-ethyl)-benzaMide

1350765-15-9

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Basic information

Product Name: 4-[4-Chloro-2-(4-chloro-3-trifluoroMethyl-benzenesulfonylaMino)-phenoxy]-3-Methoxy-N-(2-piperidin-1-yl-ethyl)-benzaMide
Synonyms: 4-[4-Chloro-2-(4-chloro-3-trifluoroMethyl-benzenesulfonylaMino)-phenoxy]-3-Methoxy-N-(2-piperidin-1-yl-ethyl)-benzaMide
CAS NO:1350765-15-9
Molecular Formula: C₂₈H₂₈Cl₂F₃N₃O₅S
Molecular Weight: 646.5052296
EINECS: -0
Product Categories: N/A
Mol File: 1350765-15-9.mol

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: /
Density: 1.402±0.06 g/cm3(Predicted)
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
PKA: 6.12±0.10(Predicted)
CAS DataBase Reference: 4-[4-Chloro-2-(4-chloro-3-trifluoroMethyl-benzenesulfonylaMino)-phenoxy]-3-Methoxy-N-(2-piperidin-1-yl-ethyl)-benzaMide(CAS DataBase Reference)
NIST Chemistry Reference: 4-[4-Chloro-2-(4-chloro-3-trifluoroMethyl-benzenesulfonylaMino)-phenoxy]-3-Methoxy-N-(2-piperidin-1-yl-ethyl)-benzaMide(1350765-15-9)
EPA Substance Registry System: 4-[4-Chloro-2-(4-chloro-3-trifluoroMethyl-benzenesulfonylaMino)-phenoxy]-3-Methoxy-N-(2-piperidin-1-yl-ethyl)-benzaMide(1350765-15-9)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1350765-15-9(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1350765-15-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,0,7,6 and 5 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1350765-15:
(9*1)+(8*3)+(7*5)+(6*0)+(5*7)+(4*6)+(3*5)+(2*1)+(1*5)=149
149 % 10 = 9
So 1350765-15-9 is a valid CAS Registry Number.

1350765-15-9Upstream product

1350765-15-9Downstream Products

1350765-15-9Relevant academic research and scientific papers

CCR2 receptor antagonists: Optimization of biaryl sulfonamides to increase activity in whole blood

Wang, Gren Z.,Haile, Pamela A.,Daniel, Tom,Belot, Benjamin,Viet, Andrew Q.,Goodman, Krista B.,Sha, Deyou,Dowdell, Sarah E.,Varga, Norbert,Hong, Xuan,Chakravorty, Subhas,Webb, Christine,Cornejo, Carla,Olzinski, Alan,Bernard, Roberta,Evans, Christopher,Emmons, Amanda,Briand, Jacques,Chung, Chun-Wa,Quek, Ruben,Lee, Dennis,Gough, Peter J.,Sehon, Clark A.

, p. 7291 - 7294 (2012/02/04)

A series of biarylsulfonamides was identified as hCCR2 receptor antagonist but suffered from high plasma protein binding resulting in a >100 fold shift in activity in a functional GTPγS assay run in tandem in the presence and absence of human serum albumin. Introduction of an aryl amide with ethylenediamine linker led to compounds with reduced shifts and improved activity in whole blood.

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