1350765-15-9

Basic information

• Product Name: 4-[4-Chloro-2-(4-chloro-3-trifluoroMethyl-benzenesulfonylaMino)-phenoxy]-3-Methoxy-N-(2-piperidin-1-yl-ethyl)-benzaMide
• Synonyms: 4-[4-Chloro-2-(4-chloro-3-trifluoroMethyl-benzenesulfonylaMino)-phenoxy]-3-Methoxy-N-(2-piperidin-1-yl-ethyl)-benzaMide
• CAS NO: 1350765-15-9
• Molecular Formula: C₂₈H₂₈Cl₂F₃N₃O₅S
• Molecular Weight: 646.5052296
• EINECS: -0
• Mol File: 1350765-15-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.402±0.06 g/cm3(Predicted)
• PKA: 6.12±0.10(Predicted)
• CAS DataBase Reference: 4-[4-Chloro-2-(4-chloro-3-trifluoroMethyl-benzenesulfonylaMino)-phenoxy]-3-Methoxy-N-(2-piperidin-1-yl-ethyl)-benzaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-Chloro-2-(4-chloro-3-trifluoroMethyl-benzenesulfonylaMino)-phenoxy]-3-Methoxy-N-(2-piperidin-1-yl-ethyl)-benzaMide(1350765-15-9)
• EPA Substance Registry System: 4-[4-Chloro-2-(4-chloro-3-trifluoroMethyl-benzenesulfonylaMino)-phenoxy]-3-Methoxy-N-(2-piperidin-1-yl-ethyl)-benzaMide(1350765-15-9)

Safety Data

• Hazardous Substances Data: 1350765-15-9(Hazardous Substances Data)

Upstream product

• 27578-60-5 1-(2-aminoethyl)piperidine 
• 1350765-39-7 C₂₁H₁₄Cl₂F₃NO₆S 
• 1038193-99-5 C₁₅H₁₂ClNO₆ 
• 1350765-60-4 C₁₅H₁₄ClNO₄ 
• 1350765-51-3 C₂₂H₁₆Cl₂F₃NO₆S 
• 3943-74-6 4-hydroxy-3-methoxybenzoic acid methyl ester 
• 345-18-6 2-fluoro-5-chloronitrobenzene 

Relevant articles and documents

CCR2 receptor antagonists: Optimization of biaryl sulfonamides to increase activity in whole blood

A series of biarylsulfonamides was identified as hCCR2 receptor antagonist but suffered from high plasma protein binding resulting in a >100 fold shift in activity in a functional GTPγS assay run in tandem in the presence and absence of human serum albumin. Introduction of an aryl amide with ethylenediamine linker led to compounds with reduced shifts and improved activity in whole blood.