Cas 1350765-89-7,(2S)-neopentyl 2-((((2R,3R,4R,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(benzylamino)phosphorylamino)propanoate

1350765-89-7

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Product Name: (2S)-neopentyl 2-((((2R,3R,4R,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(benzylamino)phosphorylamino)propanoate
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CAS NO:1350765-89-7
Molecular Formula:
Molecular Weight: 621.63
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Melting Point: N/A
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CAS DataBase Reference: (2S)-neopentyl 2-((((2R,3R,4R,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(benzylamino)phosphorylamino)propanoate(CAS DataBase Reference)
NIST Chemistry Reference: (2S)-neopentyl 2-((((2R,3R,4R,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(benzylamino)phosphorylamino)propanoate(1350765-89-7)
EPA Substance Registry System: (2S)-neopentyl 2-((((2R,3R,4R,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(benzylamino)phosphorylamino)propanoate(1350765-89-7)

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Hazardous Substances Data: 1350765-89-7(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1350765-89-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,0,7,6 and 5 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1350765-89:
(9*1)+(8*3)+(7*5)+(6*0)+(5*7)+(4*6)+(3*5)+(2*8)+(1*9)=167
167 % 10 = 7
So 1350765-89-7 is a valid CAS Registry Number.

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1350765-89-7Relevant academic research and scientific papers

PHOSPHORODIAMIDATE DERIVATIVES OF GUANOSINE NUCLEOSIDE COMPOUNDS FOR TREATMENT OF VIRAL INJECTIONS

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Page/Page column 73-74, (2012/04/23)

This invention is directed to novel compounds of formula (I) having the structure that are useful in the treatment of viral infections in mammals mediated, at least in part, by a virus in the Flaviviridae family of viruses. Methods of treating viral infec

Phosphorodiamidates as a promising new phosphate prodrug motif for antiviral drug discovery: Application to anti-HCV agents

McGuigan, Christopher,Madela, Karolina,Aljarah, Mohamed,Bourdin, Claire,Arrica, Maria,Barrett, Emma,Jones, Sarah,Kolykhalov, Alexander,Bleiman, Blair,Bryant, K. Dawn,Ganguly, Babita,Gorovits, Elena,Henson, Geoffrey,Hunley, Damound,Hutchins, Jeff,Muhammad, Jerry,Obikhod, Aleksandr,Patti, Joseph,Walters, C. Robin,Wang, Jin,Vernachio, John,Ramamurty, Changalvala V.S.,Battina, Srinivas K.,Chamberlain, Stanley

, p. 8632 - 8645 (2012/02/04)

We herein report phosphorodiamidates as a significant new phosphate prodrug motif. Sixty-seven phosphorodiamidates are reported of two 6-O-alkyl 2′-C-methyl guanosines, with significant variation in the diamidate structure. Both symmetrical and asymmetric phosphorodiamidates are reported, derived from various esterified amino acids, both D and L, and also from various simple amines. All of the compounds were evaluated versus hepatitis C virus in replicon assay, and nanomolar activity levels were observed. Many compounds were noncytotoxic at 100 μM, leading to high antiviral selectivities. The agents are stable in acidic, neutral, and moderately basic media and in selected biological media but show efficient processing by carboxypeptidases and efficiently yield the free nucleoside monophosphate in cells. On the basis of in vitro data, eight leads were selected for additional in vivo evaluation, with the intent of selecting one candidate for progression toward clinical studies. This phosphorodiamidate prodrug method may have broad application outside of HCV and antivirals as it offers many of the advantages of phosphoramidate ProTides but without the chirality issues present in most cases.

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