1350800-76-8

Basic information

• Product Name: 3H-Cyclopropa[4,5]pyrrolo[1,2-a]pyrazin-3-one, 6-aMino-1,1a,4,6a,7,7a-hexahydro-4-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)-, (1aS,4S,6aR,7aS)-
• Synonyms: 3H-Cyclopropa[4,5]pyrrolo[1,2-a]pyrazin-3-one, 6-aMino-1,1a,4,6a,7,7a-hexahydro-4-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)-, (1aS,4S,6aR,7aS)-;(1aS,4S,6aR,7aS)-6-AMino-1,1a,4,6a,7,7a-hexahydro-4-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)-3H-Cyclopropa[4,5]pyrrolo[1,2-a]pyrazin-3-one;Saxagliptin Imine Impurity
• CAS NO: 1350800-76-8
• Molecular Formula: C18H25N3O2
• Molecular Weight: 315.41
• EINECS: -0
• Mol File: 1350800-76-8.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 540.8±60.0 °C(Predicted)
• Appearance: /
• Density: 1.86±0.1 g/cm3(Predicted)
• PKA: 15.14±0.40(Predicted)
• CAS DataBase Reference: 3H-Cyclopropa[4,5]pyrrolo[1,2-a]pyrazin-3-one, 6-aMino-1,1a,4,6a,7,7a-hexahydro-4-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)-, (1aS,4S,6aR,7aS)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-Cyclopropa[4,5]pyrrolo[1,2-a]pyrazin-3-one, 6-aMino-1,1a,4,6a,7,7a-hexahydro-4-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)-, (1aS,4S,6aR,7aS)-(1350800-76-8)
• EPA Substance Registry System: 3H-Cyclopropa[4,5]pyrrolo[1,2-a]pyrazin-3-one, 6-aMino-1,1a,4,6a,7,7a-hexahydro-4-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)-, (1aS,4S,6aR,7aS)-(1350800-76-8)

Safety Data

• Hazardous Substances Data: 1350800-76-8(Hazardous Substances Data)

Usage

Description

Saxagliptin metabolite D1, also known as (1aS,4S,6aR,7aS)-6-Amino-1,1a,4,6a,7,7a-hexahydro-4-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)-3H-Cyclopropa[4,5]pyrrolo[1,2-a]pyrazin-3-one, is a derivative of Saxagliptin (S143500). Saxagliptin is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor that has been approved for the treatment of type 2 diabetes mellitus. As a metabolite, Saxagliptin D1 is formed during the metabolism of Saxagliptin in the body, and it may possess similar or different pharmacological properties compared to its parent compound.

Uses

Used in Pharmaceutical Industry:
Saxagliptin metabolite D1 is used as a therapeutic agent for the treatment of type 2 diabetes mellitus. As a metabolite of Saxagliptin, it may contribute to the overall efficacy and safety profile of the drug. It is particularly useful in managing blood glucose levels by inhibiting the DPP-4 enzyme, which is involved in the degradation of insulinotropic hormones.
Used in Research and Development:
Saxagliptin metabolite D1 serves as an important compound in the research and development of new drugs targeting type 2 diabetes and related metabolic disorders. Understanding the properties, pharmacokinetics, and pharmacodynamics of this metabolite can help researchers design more effective and safer treatments for patients with diabetes.
Used in Drug Metabolism Studies:
Saxagliptin metabolite D1 is used as a subject of study in drug metabolism research. Investigating the metabolic pathways and the formation of metabolites like D1 can provide valuable insights into the body's processing of drugs and their potential effects on health and disease.
Used in Drug Interaction Studies:
Saxagliptin metabolite D1 is used in studying potential drug interactions with other medications. Understanding how this metabolite interacts with other drugs can help healthcare providers make informed decisions about drug combinations and dosing regimens, ultimately improving patient outcomes.