1350815-39-2

Basic information

• Product Name: (2R,4S)-ethyl 4-methyl-1-((S)-1-phenylethyl)piperidine-2-carboxylate
• Synonyms: (2R,4S)-ethyl 4-methyl-1-((S)-1-phenylethyl)piperidine-2-carboxylate
• CAS NO: 1350815-39-2
• Molecular Weight: 275.391
• Mol File: 1350815-39-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2R,4S)-ethyl 4-methyl-1-((S)-1-phenylethyl)piperidine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4S)-ethyl 4-methyl-1-((S)-1-phenylethyl)piperidine-2-carboxylate(1350815-39-2)
• EPA Substance Registry System: (2R,4S)-ethyl 4-methyl-1-((S)-1-phenylethyl)piperidine-2-carboxylate(1350815-39-2)

Safety Data

• Hazardous Substances Data: 1350815-39-2(Hazardous Substances Data)

Upstream product

• 225377-18-4 1,1-dimethylethyl N-(2-ethoxy-2-oxoethyl)-N-<1(S)-phenylethyl>carbamate 
• 22263-68-9 ethyl 2-<<1(S)-phenylethyl>amino>acetate 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 37662-06-9 ethyl <(S)-1-phenylethyl>iminoethanoate 
• 139334-63-7 ethyl (2R)-4-methyl-1-((S)-1-phenylethyl)-1,2,3,6-tetrahydropyridine-2-carboxylate 

Downstream Products

• 79199-61-4 ethyl 4-methylpipeloate 

Relevant articles and documents

Diastereoselective approach to cis-4-methyl/thiol-pipecolic esters based on RCM reaction and conjugate michael addition

A synthetic route for the access to enantiopure cis-4-methyl/thiol- pipecolic esters is presented. It is based on the ring-closing metathesis reaction to build the β-unsaturated piperidin-2-one derived from (S)-(-)-phenylethylamine, followed by either diastereoselective conjugate addition of methylorganocuprate allowing access to cis-4-methyl pipecolic ester or by tandem diastereoselective hydrosulforization-thionization reaction providing access to cis-4-thiol pipecolic ethyl esters.