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CAS

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1350822-02-4

ethyl 4-(iodomethyl)bicyclo[2.2.2]octane-1-carboxylate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1350822-02-4 Structure

  • Basic information

    1. Product Name: ethyl 4-(iodomethyl)bicyclo[2.2.2]octane-1-carboxylate
    2. Synonyms: ethyl 4-(iodomethyl)bicyclo[2.2.2]octane-1-carboxylate
    3. CAS NO:1350822-02-4
    4. Molecular Formula:
    5. Molecular Weight: 322.186
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1350822-02-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: ethyl 4-(iodomethyl)bicyclo[2.2.2]octane-1-carboxylate(CAS DataBase Reference)
    10. NIST Chemistry Reference: ethyl 4-(iodomethyl)bicyclo[2.2.2]octane-1-carboxylate(1350822-02-4)
    11. EPA Substance Registry System: ethyl 4-(iodomethyl)bicyclo[2.2.2]octane-1-carboxylate(1350822-02-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1350822-02-4(Hazardous Substances Data)

1350822-02-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1350822-02-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,0,8,2 and 2 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1350822-02:
(9*1)+(8*3)+(7*5)+(6*0)+(5*8)+(4*2)+(3*2)+(2*0)+(1*2)=124
124 % 10 = 4
So 1350822-02-4 is a valid CAS Registry Number.

1350822-02-4Downstream Products

1350822-02-4Relevant articles and documents

Design, synthesis and in vitro evaluation of bridgehead fluoromethyl analogs of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl) cyclohexanecarboxamide (WAY-100635) for the 5-HT1A receptor

Al Hussainy, Rana,Verbeek, Joost,Van Der Born, Dion,Booij, Jan,Herscheid

, p. 5728 - 5735 (2012/01/14)

Fluorinated analogs that are related to the 5-hydroxytryptamine (5-HT 1A) antagonist, N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N- (pyridin-2-yl)cyclohexanecarboxamide (WAY-100635), have been synthesized and their binding affinity for the 5-HT1A receptor and other neurotransmitter receptors (adrenoceptors, sigma receptors, and dopamine receptors), and serotonin transporters was examined in vitro. These ligands were designed to provide a possible potential positron emission tomography (PET) ligand with high metabolic stability. To this end, the cyclohexyl moiety in WAY-100635 and in O-desmethyl WAY-100635 was replaced by a bridge-fused ring (BFR) such as adamantyl, cubyl, bicyclo[2.2.2]octyl and bicyclo[2.2.1]heptyl to reduce the metabolic rate of the amide bond hydrolysis, while a fluoromethyl group was introduced on the other bridgehead of the BFR to prevent defluorination by HF elimination. All synthesized analogs displayed high affinity in the (sub)nanomolar range for the 5-HT1A receptor, comparable to WAY-100635. In addition, 6b, 6c and 6d were reasonably selective to the 5-HT1A receptor over the above mentioned receptors. In human hepatocytes, 6b showed a suitable metabolic stability. In conclusion, the obtained data provides a promising starting point for the synthesis of the corresponding 18F-labeled PET analogs.

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