1350890-83-3Relevant academic research and scientific papers
Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity
Pors, Klaus,Loadman, Paul M.,Shnyder, Steven D.,Sutherland, Mark,Sheldrake, Helen M.,Guino, Meritxell,Kiakos, Konstantinos,Hartley, John A.,Searcey, Mark,Patterson, Laurence H.
, p. 12062 - 12064 (2011/12/14)
The identification of an agent that is selectively activated by a cytochrome P450 (CYP) has the potential for tissue specific dose intensification as a means of significantly improving its therapeutic value. Towards this goal, we disclose evidence for the
