1350903-38-6

Basic information

• Product Name: N-(2-acetyl-3,4-dimethoxyphenyl)-5-methylselenophene-2-carboxamide
• Synonyms: N-(2-acetyl-3,4-dimethoxyphenyl)-5-methylselenophene-2-carboxamide
• CAS NO: 1350903-38-6
• Molecular Weight: 366.275
• Mol File: 1350903-38-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2-acetyl-3,4-dimethoxyphenyl)-5-methylselenophene-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-acetyl-3,4-dimethoxyphenyl)-5-methylselenophene-2-carboxamide(1350903-38-6)
• EPA Substance Registry System: N-(2-acetyl-3,4-dimethoxyphenyl)-5-methylselenophene-2-carboxamide(1350903-38-6)

Safety Data

• Hazardous Substances Data: 1350903-38-6(Hazardous Substances Data)

Upstream product

• 30468-07-6 5-methyl-selenophene-2-carbonyl chloride 
• 98300-41-5 6'-amino-2',3'-dimethoxyacetophenone 
• 22988-84-7 5-methylselenophene-2-carboxylic acid 

Relevant articles and documents

Synthesis and in vitro anticancer activity of 6,7-methylenedioxy (or 5-hydroxy-6-methoxy)-2-(substituted selenophenyl)quinolin-4-one analogs

6,7-Methylenedioxy (or 5-hydroxy-6-methoxy)-2-(substituted selenophenyl)quinolin-4-ones and their isosteric compounds were synthesized and evaluated for anticancer activity. Structure-activity relationships (SAR) of these compounds were established. Among all tested compounds, 6,7-methylenedioxy-2-(5-methylselenophen-2-yl)quinolin-4-one (4d) was found to be the most promising anticancer agent. In screening against NCI's 60 human tumor cell line panel, 4d exhibited highly selective and potent inhibitory activity against MDA-MB-435 melanoma. Furthermore, the results of COMPARE analysis suggested that 4d is an antimitotic agent with a different mechanism of action from the conventional antimitotic agents, such as colchicine, vinca alkaloids and paclitaxel. Therefore, 4d was identified as a new lead compound that merits further optimization.