1350908-60-9

Basic information

• Product Name: 4-[(chloro)(difluoro)methyl]-3-methyl-1-phenyl-6,7-dihydro-1H-pyrazolo[3,4 b]pyridin-6-one
• CAS NO: 1350908-60-9
• Molecular Weight: 309.703
• Mol File: 1350908-60-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-[(chloro)(difluoro)methyl]-3-methyl-1-phenyl-6,7-dihydro-1H-pyrazolo[3,4 b]pyridin-6-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(chloro)(difluoro)methyl]-3-methyl-1-phenyl-6,7-dihydro-1H-pyrazolo[3,4 b]pyridin-6-one(1350908-60-9)
• EPA Substance Registry System: 4-[(chloro)(difluoro)methyl]-3-methyl-1-phenyl-6,7-dihydro-1H-pyrazolo[3,4 b]pyridin-6-one(1350908-60-9)

Safety Data

• Hazardous Substances Data: 1350908-60-9(Hazardous Substances Data)

Upstream product

• 1131-18-6 1-Phenyl-3-methyl-5-aminopyrazole 
• 2063-17-4 4-chloro-4,4-difluoro-3-oxo-butyric acid ethyl ester 

Relevant articles and documents

Synthesis of new fluorine-containing pyrazolo[3,4-b]pyridinones as promising drug precursors

Methods for the synthesis of 4-R-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-6- ones (R = CF2SAr and 4-CFHSAr) were developed. The derivatives with R = CF2SAr were obtained by both heterocyclization of 1-substituted 5-aminopyrazoles with ethyl 4,4-difluoro-3-oxo-4-phenylsulfanylbutanoate and replacement of the Br atom in 4-bromodifluoromethyl-6,7-dihydro-1H-pyrazolo[3,4- b]pyridin-6-ones by sodium arenethiolates. The fragment 4-CF-HSAr was introduced by replacement of the Cl atom in 4-chlorofluoromethyl-6,7-dihydro-1H- pyrazolo[3,4-b]pyridin-6-ones by sodium arenethiolates. Oxidation of 4-CF 2SPh-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-6-ones gave the corresponding sulfoxides; their structures were confirmed by X-ray diffraction data.