1350919-97-9

Basic information

• Product Name: (E)-2-(2-(biphenyl-4-yl)vinyl)-5-p-tolyl-1,3,4-oxadiazole
• Synonyms: (E)-2-(2-(biphenyl-4-yl)vinyl)-5-p-tolyl-1,3,4-oxadiazole
• CAS NO: 1350919-97-9
• Molecular Weight: 338.409
• Mol File: 1350919-97-9.mol

Chemical Properties

• CAS DataBase Reference: (E)-2-(2-(biphenyl-4-yl)vinyl)-5-p-tolyl-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-(2-(biphenyl-4-yl)vinyl)-5-p-tolyl-1,3,4-oxadiazole(1350919-97-9)
• EPA Substance Registry System: (E)-2-(2-(biphenyl-4-yl)vinyl)-5-p-tolyl-1,3,4-oxadiazole(1350919-97-9)

Safety Data

• Hazardous Substances Data: 1350919-97-9(Hazardous Substances Data)

Upstream product

• 827-58-7 2-p-tolyl-1,3,4-oxadiazole 
• 2350-89-2 p-vinylbiphenyl 
• 3619-22-5 p-toluic hydrazide 
• 1174153-19-5 trans-β-iodo-(4-phenyl)styrene 

Relevant articles and documents

Palladium-Catalyzed Cross-Coupling of 1,3,4-Oxadiazoles and Styrenes: An Efficient Method to Synthesize 2-Alkenyl-1,3,4- Oxadiazoles §

2-Alkenyl-1,3,4-oxadiazole derivatives have been prepared by cross-coupling of 1,3,4-oxadiazoles with styrenes by using palladium(II) trifluoroacetate [Pd(TFA) 2 ] as a catalyst, 1,10-phenanthroline as a ligand, silver trifluoroacetate as an oxidant, and toluene as a solvent. The products were formed in high yields and no byproducts were detected.

An Improved Synthesis of 2-Aryl- and 2-Alkenyl-1,3,4-oxadiazoles by Using Copper(II) Oxide Nanoparticles as a Catalyst 1

2-Aryl- and 2-alkenyl-1,3,4-oxadiazoles were efficiently synthesized in high yields by treatment of 1,3,4-oxadiazoles with aryl or alkenyl halides, respectively, in the presence of copper(II) oxide nanoparticles as a catalyst. The reusability of the catalyst is an important advantage in relation to practical applications of this synthesis.

Copper-catalyzed direct cross coupling of 1,3,4-oxadiazoles with trans-β-halostyrenes: Synthesis of 2-E-vinyl 1,3,4-oxadiazoles

The first direct C-H alkenylation of 1,3,4-oxadiazoles with trans-β-halo olefinic system has been carried out using a combination of CuI/DMEDA as a catalyst. A wide range of 2-E-vinyl-substituted oxadiazoles were obtained in high yields (85-93%).