1350980-08-3

Upstream product

• 135-19-3 β-naphthol 
• 169139-89-3 (+/-)-3-benzyloxy-1-nitropropan-2-ol 
• 194807-63-1 (E)-(((3-nitroallyl)oxy)methyl)benzene 
• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 100-44-7 benzyl chloride 
• 14593-43-2 benzyl allyl ether 
• 1350980-18-5 (S)-N-(3-(benzyloxy)-2-(2-hydroxynaphthalen-1-yl)propyl)-o-nitrobenzenesulfonamide 
• 1350980-15-2 (S)-1-(1-amino-3-(benzyloxy)propan-2-yl)naphthalen-2-ol 
• 1350980-13-0 (S)-1-(1-(benzyloxy)-3-nitropropan-2-yl)naphthalen-2-ol 

Relevant academic research and scientific papers

A new enantioselective approach to the core structure of hypoxia selective prodrugs related to the duocarmycins

The indoline scaffold of hypoxia selective prodrugs of DNA-alkylating agents related to the duocarmycin natural products was synthesized via an enantioselective Friedel-Crafts alkylation. Easily accessible starting materials and good stereoselectivity in the alkylation step provide an enantioselective synthesis of the DNA-alkylating subunit.