13512-48-6

Basic information

• Product Name: tert-butyl N-[(benzyloxy)carbonyl]alanylglycinate
• CAS NO: 13512-48-6
• Molecular Formula: C₁₇H₂₄N₂O₅
• Molecular Weight: 336.3829
• Mol File: 13512-48-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 510.8°C at 760 mmHg
• Flash Point: 262.7°C
• Density: 1.148g/cm³
• Vapor Pressure: 1.5E-10mmHg at 25°C
• Refractive Index: 1.513
• CAS DataBase Reference: tert-butyl N-[(benzyloxy)carbonyl]alanylglycinate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl N-[(benzyloxy)carbonyl]alanylglycinate(13512-48-6)
• EPA Substance Registry System: tert-butyl N-[(benzyloxy)carbonyl]alanylglycinate(13512-48-6)

Safety Data

• Hazardous Substances Data: 13512-48-6(Hazardous Substances Data)

Upstream product

• 6456-74-2 Glycine tert-butyl ester 
• 3401-36-3 (N-benzyloxycarbonyl)-L-alanine N-hydroxysuccinimide ester 
• 1142-20-7 N-Cbz-Ala 

Relevant articles and documents

Silver-Mediated N-Trifluoromethylation of Amides and Peptides

We report herein the direct N-trifluoromethylation of N-H amides. Promoted by AgOTf and 2-fluoropyridine, the reaction of a variety of amides with Selectfluor, TMSCF3 and CsF proceeds smoothly at room temperature leading to the corresponding N-trifluoromethylated products in satisfactory yields. The protocol is also applicable to amino acid derivatives, resulting in efficient and chemoselective N-trifluoromethylation of di- and tri-peptides with retention of configuration. A mechanism involving reductive elimination of Ag(III) intermediates to form N—CF3 bonds is proposed.