135127-65-0

Upstream product

• 942-06-3 4,5-dichlorophthalic anhydride 
• 108-24-7 acetic anhydride 

Downstream Products

• 178239-49-1 2-(2-carboxy-4,5-dichlorophenyl)-6-methyl-4-quinolinecarboxylic acid 
• 178239-42-4 2-(6-methylquinolin-2-yl)-4,5-dichlorobenzoic acid 

Relevant academic research and scientific papers

ADAMTS INHIBITORS, PREPARATION METHODS AND MEDICINAL USES THEREOF

Compounds of formula (I) useful as inhibitors of ADAMTS-5 and/or ADAMTS-4, pharmaceutical compositions thereof, and use of them as therapeutic agents for the treatment of diseases involving degradation of cartilage or disruption of cartilage homeostasis, in particular osteoarthrosis and/or rheumatoid arthritis, are disclosed.

Process for producing 2-(carboxyphenyl)-4-quinolinecarboxylic acid compounds

Quinolin-2-yl benzoic acid compounds which are useful as intermediates of quinoline compounds having angiotensin II antagonist activity prepared by decarboxylating 2-(carboxyphenyl)-4-quinolinecarboxylic acid compounds in which a carboxyl group bonded to a phenyl group may be esterified, while a carboxyl group bonded to a quinoline ring is not esterified, and both rings may have one or more substituents inert to the decarboxylation reaction.

Process for producing quinolin-2-yl benzoic acid compounds

A quinolin-2-yl benzoic acid compound useful as intermediates of angiotensin II antagonists which are effective for treating hypertension can be produced by decarboxylating a 2-carboxyphenyl-4-quinolinecarboxylic acid compound in which two carboxyl groups are not substituted and a benzene ring and a quinoline ring may have substituents inert to said decarboxylation reaction.

Untersuchungen zur Chemie von Isoindolen und Isoindoleninen, XXXVIII. 3-Alkoxy-1H-isoindole mit Substituenten am 5-Ring - Heterocycliche Imidsaeureester mit fixierter benzoider Struktur.

3-Alkoxy-1H-isoindoles bearing substituents at the five-membered ring have been synthesized starting with substituted isoindoline-1-ones via regiospecific O-alkylation with trialkyl oxonium tetrafluoroborates or alkyl trifluoromethanesulfonates and subsequent NH-deprotonation.The dependence of spectroscopic properties on the substituents has been investigated.The heterocyclic imidates exist exclusively in the benzenoid 1H-structure; the tautomeric o-quinonoid 2H-form cannot be detected by spectroscopic means.