1351373-50-6 Usage
Description
Bis-propargyl-PEG13 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
structure and hydrogen bonding
Bis-propargyl-PEG13 comprises two propargyl groups which can form triazole linkages with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry reactions. The hydrophilic PEG units help improve the solubility of the molecule in aqueous media.
Check Digit Verification of cas no
The CAS Registry Mumber 1351373-50-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,1,3,7 and 3 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1351373-50:
(9*1)+(8*3)+(7*5)+(6*1)+(5*3)+(4*7)+(3*3)+(2*5)+(1*0)=136
136 % 10 = 6
So 1351373-50-6 is a valid CAS Registry Number.
1351373-50-6Relevant articles and documents
Convergent synthesis and characterization of dumbbell type dendritic materials by click chemistry
Sung, Sae Reum,Han, Seung Choul,Jin, Sung-Ho,Lee, Jae Wook
experimental part, p. 3933 - 3940 (2012/03/26)
General, fast, and efficient stitching methods for the synthesis of dendrimers with linear PEG units at a core, as dendritic-linear-dendritic materials, were developed. The synthetic strategy involved the click reaction between an alkyne and an azide. The