135145-35-6

Basic information

• Product Name: (R)-(3-chlorophenyl)(p-tolyl)methanol
• CAS NO: 135145-35-6
• Molecular Weight: 232.71
• Mol File: 135145-35-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-(3-chlorophenyl)(p-tolyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(3-chlorophenyl)(p-tolyl)methanol(135145-35-6)
• EPA Substance Registry System: (R)-(3-chlorophenyl)(p-tolyl)methanol(135145-35-6)

Safety Data

• Hazardous Substances Data: 135145-35-6(Hazardous Substances Data)

Upstream product

• 625-99-0 3-iodochlorobenzene 
• 104-87-0 4-methyl-benzaldehyde 
• 63503-60-6 3-chlorophenylboronic acid 
• 20268-16-0 (R)-(+)-2-chlorophenyl 4-methylphenyl sulfoxide 
• 36692-27-0 2-chlorophenylmagnesium bromide 
• 925-90-6 ethylmagnesium bromide 
• 135145-28-7 [3-Chloro-2-((S)-toluene-4-sulfinyl)-phenyl]-p-tolyl-methanol 

Downstream Products

• 13389-44-1 3-Chlor-4'-methyl-benzhydrylchlorid 

Relevant articles and documents

Continuous preparation of arylmagnesium reagents in flow with inline IR monitoring

A newly developed microscale ReactIR flow cell was used as a convenient and versatile inline analytical tool for Grignard formation in continuous flow chemical processing. The LiCl-mediated halogen/Mg exchange reaction was used for the preparation of functionalized arylmagnesium compounds from aryl iodides or bromides. Furthermore, inline IR monitoring was used for the analysis of conversion and possible byproduct formation, as well as a potential tool for elucidation of mechanistic details. The results described herein indicate that the continuous flow systems are effective for highly exothermic reactions such as the Grignard exchange reaction due to fast mixing and efficient heat transfer.

Regiospecific Ortho Lithiation of o-Halophenyl p-Tolyl Sulfoxides and Synthesis of Meta-Substituted Optically Active Aryl Alcohols

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