1351478-35-7

Basic information

• Product Name: 1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-1H-imidazole
• Synonyms: 1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-1H-imidazole
• CAS NO: 1351478-35-7
• Molecular Formula: C₁₆H₂₁BN₂O₂
• Molecular Weight: 284.16114
• Mol File: 1351478-35-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 437.8±28.0 °C(Predicted)
• Appearance: /
• Density: 1.07±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 6.76±0.10(Predicted)
• CAS DataBase Reference: 1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-1H-imidazole(1351478-35-7)
• EPA Substance Registry System: 1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-1H-imidazole(1351478-35-7)

Safety Data

• Hazardous Substances Data: 1351478-35-7(Hazardous Substances Data)

Usage

General Description

1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-1H-imidazole is a chemical compound with potential applications in the field of chemistry and pharmaceuticals. It is a derivative of imidazole, a five-membered heterocyclic ring containing two nitrogen atoms, and features a boron-containing group. The presence of the boron group makes it a potentially useful compound for various synthetic reactions, including Suzuki-Miyaura cross-coupling reactions. Additionally, imidazole derivatives are known to have pharmaceutical properties, and this compound could potentially be explored for its pharmacological activities. Its specific structural features make it an interesting and potentially valuable compound for further research and development in various scientific and industrial applications.

Upstream product

• 106-38-7 para-bromotoluene 
• 72459-46-2 1-bromo-4-(imidazol-1-ylmethyl)benzene 
• 73183-34-3 bis(pinacol)diborane 
• 589-15-1 1-bromomethyl-4-bromobenzene 

Downstream Products

• 1351476-79-3 5-(4-((1H-imidazol-1-yl)methyl)phenyl)-3-(1H-indol-5-yl)-1H-pyrrolo[2,3-b]pyridine 

Relevant articles and documents

Derisking the Cu-Mediated 18F-Fluorination of Heterocyclic Positron Emission Tomography Radioligands

Molecules labeled with fluorine-18 (18F) are used in positron emission tomography to visualize, characterize and measure biological processes in the body. Despite recent advances in the incorporation of 18F onto arenes, the development of general and efficient approaches to label radioligands necessary for drug discovery programs remains a significant task. This full account describes a derisking approach toward the radiosynthesis of heterocyclic positron emission tomography (PET) radioligands using the copper-mediated 18F-fluorination of aryl boron reagents with 18F-fluoride as a model reaction. This approach is based on a study examining how the presence of heterocycles commonly used in drug development affects the efficiency of 18F-fluorination for a representative aryl boron reagent, and on the labeling of more than 50 (hetero)aryl boronic esters. This set of data allows for the application of this derisking strategy to the successful radiosynthesis of seven structurally complex pharmaceutically relevant heterocycle-containing molecules.