1351585-64-2Relevant academic research and scientific papers
Self-disproportionation of enantiomers of non-racemic chiral amine derivatives through achiral chromatography
Nakamura, Tsuyoshi,Tateishi, Kaori,Tsukagoshi, Shiori,Hashimoto, Saori,Watanabe, Shotaro,Soloshonok, Vadim A.,Ace?a, José Luis,Kitagawa, Osamu
, p. 4013 - 4017 (2012)
Efficient self-disproportionation of enantiomers of several non-racemic chiral amines was achieved through conversion to N-acetamides and subsequent MPLC using an achiral column. The MPLC of these non-racemic N-acetamide derivatives gave the chart having a clear boundary between two fractions. Thus, in the less polar fraction, remarkable enantiomer enrichment was observed (>99%ee), while the ee of more polar fraction was considerably reduced. The magnitude of the enantiomer enrichments and depletions strongly depended on substituent on the amino group.
