13516-17-1

Upstream product

• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 3519-30-0 L-α-hydroxyisovaleric acid t-butyl ester 

Downstream Products

• 32693-80-4 benzyloxycarbonyl-L-valyl-L-α-hydroxyisovaleric acid 
• 174757-67-6 benzyloxycarbonyl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleric acid t-butyl ester 
• 105087-53-4 benzyloxycarbonyl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleric acid 
• 125760-11-4 benzyloxycarbonyl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleric acid pentafluorophenyl ester 

Relevant academic research and scientific papers

Applications of pentafluorophenylester coupling in the synthesis of cyclodepsipeptides related to valinomycins

A number of strategies of synthesis of cyclic depsipeptides are examined including cyclisation protocols based on pentafluorophenyl esters. The alternatives of amine protection as benzyloxycarbonyl or t-butoxycarbonyl derivatives are examined and optimum