1351643-80-5

Basic information

• Product Name: 11,12,12-tris-(p-methoxyphenyl)dodec-11-enyl 6'-(t-butoxycarbonylaminomethyl)nicotinate
• CAS NO: 1351643-80-5
• Molecular Weight: 736.949
• Mol File: 1351643-80-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 11,12,12-tris-(p-methoxyphenyl)dodec-11-enyl 6'-(t-butoxycarbonylaminomethyl)nicotinate(CAS DataBase Reference)
• NIST Chemistry Reference: 11,12,12-tris-(p-methoxyphenyl)dodec-11-enyl 6'-(t-butoxycarbonylaminomethyl)nicotinate(1351643-80-5)
• EPA Substance Registry System: 11,12,12-tris-(p-methoxyphenyl)dodec-11-enyl 6'-(t-butoxycarbonylaminomethyl)nicotinate(1351643-80-5)

Safety Data

• Hazardous Substances Data: 1351643-80-5(Hazardous Substances Data)

Upstream product

• 151229-06-0 11,12,12-tris(4-methoxyphenyl)-11-dodecen-1-ol 
• 170097-87-7 6-(((tert-butoxycarbonyl)amino)methyl)nicotinic acid 

Relevant articles and documents

Lipophilic Pt(II) complexes with selective efficacy against cisplatin-resistant testicular cancer cells

A series of dichloridoplatinum(II) complexes with selective and high cytotoxicity [IC90(96 h) ≤ 3 μM] against cisplatin-resistant 1411HP testicular cancer cells were identified. They bear stationary 6-aminomethylnicotinate or 2,4-diaminobutyrate ligands esterified with lipophilic terpenyl residues, i.e., (-)/(+)-menthyl, (+)-cedrenyl, (-)-menthoxypropyl, or with a decyl-tethered 1,1,2-triphenylethene. They accumulated to a larger extent in 1411HP cells than in cells of the cisplatin-sensitive H12.1 germ cell tumour. Their mechanism of apoptosis induction differed from that of cisplatin by being independent of p53 and of caspase-3 activation and by an early loss of the mitochondrial membrane potential. The new complexes are promising candidates for the treatment of cisplatin-resistant testicular tumours.