1351646-50-8

Basic information

• Product Name: 4-[1-(2,5-dimethylbenzyl)-4-methoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid
• Synonyms: 4-[1-(2,5-dimethylbenzyl)-4-methoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid
• CAS NO: 1351646-50-8
• Molecular Weight: 379.412
• Mol File: 1351646-50-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-[1-(2,5-dimethylbenzyl)-4-methoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[1-(2,5-dimethylbenzyl)-4-methoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid(1351646-50-8)
• EPA Substance Registry System: 4-[1-(2,5-dimethylbenzyl)-4-methoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid(1351646-50-8)

Safety Data

• Hazardous Substances Data: 1351646-50-8(Hazardous Substances Data)

Upstream product

• 50837-53-1 2,5-dimethylbenzyl bromide 
• 1351646-20-2 4-[1-(2,5-dimethylbenzyl)-4-methoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate 
• 4837-90-5 4-methoxy-1H-indole 
• 73260-12-5 3-acetyl-4-methoxy-1H-indole 

Relevant articles and documents

Microwave assisted organic synthesis (MAOS) of small molecules as potential HIV-1 integrase inhibitors

Integrase (IN) represents a clinically validated target for the development of antivirals against human immunodeficiency virus (HIV). In recent years our research group has been engaged in the stucture-function study of this enzyme and in the development of some three-dimensional pharmacophore models which have led to the identification of a large series of potent HIV-1 integrase strand-transfer inhibitors (INSTIs) bearing an indole core. To gain a better understanding of the structure-activity relationships (SARs), herein we report the design and microwave-assisted synthesis of a novel series of 1-H-benzylindole derivatives.