1351775-64-8Relevant academic research and scientific papers
Oxidative coupling reactions of 1,3-diarylpropene derivatives to dibenzo[a,c]cycloheptenes by PIFA
Hackeloeer, Kristina,Schnakenburg, Gregor,Waldvogel, Siegfried R.
supporting information; experimental part, p. 6314 - 6319 (2011/12/01)
The oxidative cyclization reactions of a variety of α- benzylcinnamates can be selectively performed with hypervalent iodine as an oxidant. The dibenzo[a,c]cycloheptenes were isolated in up to 55 % yield. When an oxo substrate is applied, the yield was significantly increased. With this synthetic approach, a central intermediate for the synthesis of metasequirin-B was obtained in three steps from very simple starting materials. For this transformation, both aryl moieties have to be activated.
