135181-93-0Relevant academic research and scientific papers
Short synthesis of isocarbacyclin by regioselective SN2′ alkylation of bicyclic allylic esters with zinc-copper reagents
Tanaka, Toshio,Bannai, Kiyoshi,Hazato, Atsuo,Koga, Masahiro,Kurozumi, Seizi,Kato, Yoshinori
, p. 1861 - 1876 (1991)
Isocarbacyclin [(+)-9(0)-methano-Δ6(9α)-prostaglandin I1] (2) was synthesized from bicyclic synthons such as 2-phosphorylated, 2-(thio)phosphorylated, 2-tosylated, 2-methoxycarbonylated, and 2-chloro-3-methylenebicyclo[3.3,0]octanes via highly regioselective SN2′ alkylation with zinc-copper reagents 9 in excellent yields.
