1352004-93-3Relevant academic research and scientific papers
Synthesis and antimicrobial screening of 4-thiazolidinone and 2-azetidinone derivatives of piperazine
Shingade, Sunil G.,Bari, Sanjaykumar B.
, p. 699 - 706 (2013)
The Schiff's bases 3a-3h were synthesized by reacting substituted/ unsubstituted aromatic aldehydes 2a-2h with 1-(2-aminoethyl)-piperazine 1. A series of novel aryl-3-(2-piperazin-1-ylethyl)-1,3-thiazolidin-4-one 4a-4h and 3-chloro-1-{2-[4-(chloroacetyl)piperazin-1-yl]ethyl}-4-arylazetidin-2-one 5a-5h were synthesized from the Schiff's bases of 1-(2-aminoethyl)-piperazine 3a-3h. The structures of synthesized compounds were confirmed by analytical (C, H, and N) and spectral (FT-IR, 1H NMR, 13C NMR, and Mass) data. The compounds 4a-4h and 5a-5h were screened for antimicrobial activity. The compounds 4a, 4d, 4f, 4g, 5a, 5d, 5f, and 5g exhibited substantially significant antibacterial as well as antifungal activity.
Synthesis, anti-inflammatory and anticancer activity evaluation of some mono-And bis-Schiff's bases
Sondhi, Sham M.,Arya, Surbhi,Rani, Reshma,Kumar, Nikhil,Roy, Partha
, p. 3620 - 3628 (2013/02/23)
Several mono-Schiff's bases (3a-i) and bis-Schiff's bases (5a-f) were synthesized using microwave irradiation technique (3a-h, 5a-c) and by simply grinding at room temperature for a few minutes (3i, 5d-f). All these compounds were characterized by spectroscopic means and elemental analysis. They were screened for anti-inflammatory and anticancer activities (against five human cancer cell lines). Compound 5f exhibited good anti-inflammatory and compounds 3f, 5a-f exhibited good anticancer activity. Springer Science+Business Media, LLC 2011.
