1352007-00-1Relevant academic research and scientific papers
Discovery, synthesis and SAR of azinyl- and azolylbenzamides antagonists of the P2X7 receptor
Subramanyam, Chakrapani,Duplantier, Allen J.,Dombroski, Mark A.,Chang, Shang-Poa,Gabel, Christopher A.,Whitney-Pickett, Carrie,Perregaux, David G.,Labasi, Jeff M.,Yoon, Kwansik,Shepard, Richard M.,Fisher, Michael
, p. 5475 - 5479 (2011/10/12)
The discovery, of a series of 2-Cl-5-heteroaryl-benzamide antagonists of the P2X7 receptor via parallel medicinal chemistry is described. Initial analogs suffered from poor metabolic stability and low Vdss. Multi parametric optimizat
