1352009-98-3Relevant articles and documents
Fishing with copper acetylides: Selective alkynylation of heteronucleophiles
Guissart, Céline,Luhmer, Michel,Evano, Gwilherm
supporting information, p. 6727 - 6736 (2018/10/15)
Copper acetylides are readily available and especially convenient reagents for the alkynylation of a broad range of heteronucleophiles. Upon simple activation with molecular oxygen in the presence of suitable ligands and solvents, they readily transfer th
Oxidative alkynylation of imines with alkynylcopper reagents: A straightforward and practical entry to ynimines
Laouiti, Anouar,Jouvin, Kvin,Bourdreux, Flavien,Rammah, Mohamedm.,Rammah, Mohamedb.,Evano, Gwilherm
experimental part, p. 1491 - 1500 (2012/06/16)
We have developed an efficient and general synthesis of ynimines based on an oxidative cross-coupling between imines and alkynylcopper reagents. Upon simple addition of 1,2-dimethylimidazole in the presence of oxygen, these bench-stable, crystalline, and readily available polymeric compounds were found to be especially suitable reagents for the introduction of an alkynyl group into a wide range of ketimines at room temperature and under especially mild conditions.
