1352009-99-4Relevant academic research and scientific papers
Oxidative alkynylation of imines with alkynylcopper reagents: A straightforward and practical entry to ynimines
Laouiti, Anouar,Jouvin, Kvin,Bourdreux, Flavien,Rammah, Mohamedm.,Rammah, Mohamedb.,Evano, Gwilherm
experimental part, p. 1491 - 1500 (2012/06/16)
We have developed an efficient and general synthesis of ynimines based on an oxidative cross-coupling between imines and alkynylcopper reagents. Upon simple addition of 1,2-dimethylimidazole in the presence of oxygen, these bench-stable, crystalline, and readily available polymeric compounds were found to be especially suitable reagents for the introduction of an alkynyl group into a wide range of ketimines at room temperature and under especially mild conditions.
Copper-catalyzed oxidative alkynylation of diaryl imines with terminal alkynes: A facile synthesis of ynimines
Laouiti, Anouar,Rammah, Mohamed M.,Rammah, Mohamed B.,Marrot, Jerome,Couty, Francois,Evano, Gwilherm
supporting information; experimental part, p. 6 - 9 (2012/02/14)
An efficient copper-mediated method for the oxidative alkynylation of diaryl imines with terminal alkynes is reported. This reaction provides the first catalytic and general synthesis of ynimines and allows for an easy preparation of these useful building blocks. An improved copper-catalyzed oxidative dimerization of imines to azines and the synthesis of dienes and azadienes from ynimines are also described.
