135207-17-9

Usage

Uses

Used in Pharmaceutical Industry:
1H-Imidazole, 1-cyclopropylis used as a key intermediate in the synthesis of various pharmaceuticals for its ability to form biologically active molecules and drugs. Its unique structure allows for the development of compounds with specific therapeutic properties.
Used in Agrochemical Industry:
1H-Imidazole, 1-cyclopropylis used as a building block in the production of agrochemicals, such as pesticides and herbicides, due to its potential to create compounds with effective pesticidal and herbicidal properties.
Used as an Antifungal Agent:
1H-Imidazole, 1-cyclopropylis used as an antifungal agent for its potential to inhibit the growth of fungi, making it a valuable component in the development of antifungal medications and treatments.
Used as an Antimicrobial Agent:
1H-Imidazole, 1-cyclopropylis used as an antimicrobial agent for its ability to combat the growth of microorganisms, including bacteria. This property makes it a useful component in the development of antimicrobial drugs and therapies.

InChI:InChI=1S/C6H8N2/c1-2-6(1)8-4-3-7-5-8/h3-6H,1-2H2

Upstream product

• 50-00-0 formaldehyd 
• 131543-46-9 Glyoxal 
• 765-30-0 Cyclopropylamine 
• 4405-13-4 glyoxal trimer dihydrate 
• 288-32-4 1H-imidazole 
• 4333-56-6 cyclopropyl bromide 

Downstream Products

• 497855-86-4 1-cyclopropylimidazole-2-carboxyaldehyde 
• 1262035-61-9 5-bromo-1-cyclopropyl-1H-imidazole 
• 1450738-74-5 4-(3-cyclopropyl-3H-imidazole-4-carbonyl)benzonitrile 
• 1450739-60-2 4-[(3-cyclopropyl-3H-imidazol-4-yl)hydroxymethyl]benzonitrile 

Relevant academic research and scientific papers

A 2 - mercapto - 1 - alkyl imidazole of preparation method (by machine translation)

The invention discloses a 2 - mercapto - 1 - alkyl imidazole synthesis method, which belongs to the technical field of organic synthesis. Imidazole and alkyl halide in the presence of an inorganic base sealing reaction the temperature of the 1 - alkyl imidazole, then dissolved in ether in the solvent, the low temperature by adding 1 - 1.1 equivalent BuLi, then adding 0.9 - 0.95 equivalent powder reflux reaction, after cooling add acetyl chloride to obtain 2 - acetyl thio - 1 - alkyl imidazole; the final 2 - acetyl thio - 1 - alkyl imidazole dissolved in alcohol solvent, adding a catalytic amount of hydrogen chloride or potassium carbonate deprotection, to obtain 2 - mercapto - 1 - alkyl imidazole. The raw material of the invention is cheap, and more friendly to the environment, the advantages of easy operation, the quality of the product in accordance with the electronic chemicals using standard. (by machine translation)

APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS

The present invention relates to compounds of Formula (I): where in X1, X2, X3, X4, X5, X6, X7, X8, R1, R2, R3 are as defined above. T

Optically active antifungal azoles. III. Synthesis and antifungal activity of sulfide and sulfonamide derivatives of (2R,3R)-2-(2,4-difluorophenyl)-3- mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol

In an effort to find potent antifungal agents, optically active sulfur- containing triazole derivatives, sulfides (3) and sulfonamides (4), were prepared and evaluated for antifungal activity against Candida albicans in vitro and in vivo. The sulfides (3) were prepared by the reaction of (2R,3R)- 2-(2,4-difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol (1) with various heteroarylmethyl chlorides in the presence of sodium methoxide. The sulfonamides (4) were synthesized starting from the disulfide (15) in three steps including oxidation of the corresponding sulfenamides (17). Some of the sulfur-containing triazole derivatives (3, 4) showed strong protective effects against candidosis in mice.