1352072-34-4

Upstream product

• 1352073-02-9 methyl 4-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-5-oxopentanoate 
• 1352076-45-9 (3S,5R,6R)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one 
• 215672-67-6 (3S,4S)-3-amino-4-hydroxypentane 
• 951000-34-3 (2S,3S)-3-aminopentan-2-ol hydrochloride 
• 108-37-2 1-bromo-3-chlorobenzene 
• 68968-12-7 2-(3-chlorophenyl)-1-(4-chlorophenyl)ethan-1-one 
• 99-91-2 para-chloroacetophenone 

Downstream Products

• 1352072-73-1 (3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((2S,3S)-2-hydroxypentan-3-yl)-3-methylpiperidin-2-one 
• 1352072-35-5 (1R,2R,4S)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-4-((4S,5S)-4-ethyl-5-methyl-4,5-dihydrooxazol-2-yl)-4-methylhept-6-en-1-ol 
• 1388625-20-4 (2R,3S,5S,6R,8S)-8-allyl-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-ethyl-2,8-dimethyl-2,3,5,6,7,8-hexahydrooxazolo[3,2-a]pyridin-4-ium trifluoromethanesulfonate 

Relevant academic research and scientific papers

An expeditious synthesis of the MDM2-p53 inhibitor AM-8553

The development of the structurally complex MDM2/p53 inhibitor AM-8553 was impeded by the low yield of the initial synthesis. A second generation synthesis is described that features a Noyori dynamic kinetic resolution, a highly diastereoselective allylation, and a novel oxazoline-assisted piperidinone forming reaction to provide AM-8553 in 35.6% yield and 11 steps.