1352166-86-9Relevant academic research and scientific papers
Resolution of enantiomers of [α-hydroxy-(o-chlorophenyl)methyl] phosphinic acid via diastereomeric salt formation with enantiopure 1-phenylethylamines
Kaboudin, Babak,Alaie, Saied,Yokomatsu, Tsutomu
, p. 1813 - 1816 (2012/01/05)
The resolution of racemic α-hydroxy-H-phosphinic acid with enantiopure 1-phenylethylamines via diastereomeric salt formation was investigated. X-Ray crystallographic analysis of the salt revealed that (R)-1-phenylethylamine to be efficient resolving agent for obtaining a single enantiomer of [α-hydroxy-(o-chlorophenyl)methyl]phosphinic acid. Resolving racemic α-hydroxy-H-phosphinic acid with (S)-2-phenylethylamine also gave access to (S)-α-hydroxyalkylphosphinic acid in good yield.
