135219-97-5Relevant articles and documents
ACETALES OF LACTAMS AND AMIDES. 60. N- AND O-ALKYLATION OF 5-OXO-5,6,7,8-TETRAHYDROCARBOSTYRILS. SYNTHESIS OF ISOXAZOLO- AND PYRAZOLOQUINOLINES
Shanazarov, A. K.,Kuzovkin, V. A.,Chistyakov, V. V.,Granik, V. G.
, p. 71 - 76 (1991)
The alkylation of 5-oxo-5,6,7,8-tetrahydrocarbostyrils has been examined by GLC.It has been found that, irrespective of the reaction conditions and the alkylating agent used, both N- and O-alkylation occur.When triethyloxonium fluoroborate and N,N-DMF diethyl acetal are used O-alkylation predominates, and with alkyl halides, N-alkylation.Reaction of N-ethyl-5-oxo-5,6,7,8-tetrahydrocarbostyril and 2-ethoxy-5-oxo-5,6,7,8-tetrahydroquinoline with DMF diethyl acetal gives the 6-dimethylaminomethylene derivatives, treatment of which with hydrazine hydrate or hydroxylamine affording isoxazolo- or pyrazoloquinolines.
