1352243-38-9

Basic information

• Product Name: C₂₄H₃₁N₃O₅*ClH
• CAS NO: 1352243-38-9
• Molecular Weight: 477.988
• Mol File: 1352243-38-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₄H₃₁N₃O₅*ClH(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₃₁N₃O₅*ClH(1352243-38-9)
• EPA Substance Registry System: C₂₄H₃₁N₃O₅*ClH(1352243-38-9)

Safety Data

• Hazardous Substances Data: 1352243-38-9(Hazardous Substances Data)

Upstream product

• 1428377-01-8 C₃₀H₄₁N₃O₇ 
• 132201-32-2 (2R,3S)-3-phenylisoserine hydrochloride 
• 145514-62-1 RPR 130523 
• 1428377-15-4 C₂₉H₃₉N₃O₇ 

Relevant articles and documents

Design, synthesis and preliminary activity evaluation of novel 3-amino-2-hydroxyl-3-phenylpropanoic acid derivatives as aminopeptidase N/CD13 inhibitors

Aminopeptidase N (APN/CD13) over expressed on tumour cells, plays a critical role in tumour invasion, metastasis and tumour angiogenesis. In this article, we described the design, synthesis and preliminary activity studies of novel 3-amino-2-hydroxyl-3-phenylpropanoic acid derivatives as APN inhibitors. The in vitro enzymatic inhibitions on APN from porcine kidney showed that compound 7e had the most potent inhibitory activity against APN with the IC50 value to 1.26±0.01 μM, which is better than that of bestatin (IC50=2.55±0.11 μM). In addition, compound 7e also showed better inhibitory activity against APN on human ovary clear cell carcinoma cell ES-2 than bestatin with the IC50 value to 30.19±1.02 μM versus 60.61±0.1 μM. Compound 7e could be used as the lead compound in the future for anti-cancer agent research.