1352276-48-2Relevant academic research and scientific papers
Synthesis of substituted 3-cyano- and 3-(arenesulfonyl)indoles from o-nitrobenzyl cyanides and sulfones
Wrobel, Zbigniew,Wojciechowski, Krzysztof
experimental part, p. 2567 - 2571 (2011/12/04)
Formation of enamines, in the reaction of o-nitrophenyl-acetonitriles with Vilsmeier reagents, followed by reductive cyclization using Zn in acetic acid, leads to variously substituted 3-cyanoindoles, possessing aryl, alkyl, and aminoalkyl substituents at C-2. The method, when starting from the appropriate o-nitrobenzylsulfones, allows the synthesis of substituted 3-(arenesulfonyl)- indoles. Georg Thieme Verlag Stuttgart · New York.
