1352281-08-3Relevant academic research and scientific papers
Three types of products by carbon nucleophiles toward methoxyphenylacetylenic sulfones
Cheng, Chia-Yi,Isobe, Minoru
, p. 9957 - 9965 (2012/02/06)
Methoxy-arylacetylenic sulfones were examined to react with various carbanion nucleophiles to result in the three types of products; thus, (i) nucleophiles (MeLi·LiBr, Vinyl MgBr, LiCH2CN) showed the α-addition, however, (ii) Li-CC-TMS afforded β-addition (conjugate addition) products. The (iii) displacement reaction through α-addition/ isomerization/trans-elimination was enhanced by the presence of ortho-methoxy group at high temperature. The heteroatom nucleophiles (nitrogen, oxygen or sulfur atom) in a protic solvent provided only conjugate addition products as reported.
