13523-62-1

Basic information

• Product Name: 2-ISOPROPYL-4-HYDROXY ANISOLE
• Synonyms: 2-ISOPROPYL-4-HYDROXY ANISOLE;3-Isopropyl-4-Methoxyphenol
• CAS NO: 13523-62-1
• Molecular Formula: C₁₀H₁₄O₂
• Molecular Weight: 166.22
• Mol File: 13523-62-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 279.8°Cat760mmHg
• Flash Point: 134.6°C
• Appearance: /
• Density: 1.026g/cm³
• Vapor Pressure: 0.00232mmHg at 25°C
• Refractive Index: 1.517
• PKA: 10.52±0.18(Predicted)
• CAS DataBase Reference: 2-ISOPROPYL-4-HYDROXY ANISOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ISOPROPYL-4-HYDROXY ANISOLE(13523-62-1)
• EPA Substance Registry System: 2-ISOPROPYL-4-HYDROXY ANISOLE(13523-62-1)

Safety Data

• Hazardous Substances Data: 13523-62-1(Hazardous Substances Data)

Usage

General Description

2-ISOPROPYL-4-HYDROXY ANISOLE, also known as propyl gallate, is a chemical compound commonly used as an antioxidant in food, cosmetic, and pharmaceutical products. It is an ester derivative of gallic acid and is synthesized by the esterification of propyl alcohol and gallic acid. 2-ISOPROPYL-4-HYDROXY ANISOLE is known for its ability to prevent the oxidation of fats and oils, thereby extending the shelf life of products that contain it. It is also used as a stabilizer in the production of plastics and rubbers. In addition, 2-ISOPROPYL-4-HYDROXY ANISOLE has been studied for its potential health benefits, including anti-inflammatory and anti-cancer effects. However, there have been concerns about its safety and potential toxicity in high doses.

InChI:InChI=1/C10H14O2/c1-7(2)9-6-8(11)4-5-10(9)12-3/h4-7,11H,1-3H3

Upstream product

• 2944-47-0 o-isopropylanisole 
• 110391-95-2 4-isopropyl-4-methoxy-2,5-cyclohexadienone 
• 31825-29-3 3‐isopropyl‐4‐methoxybenzaldehyde 
• 91251-43-3 3-Isopropyl-4-methoxy-phenylamine; hydrochloride 

Downstream Products

• 78805-60-4 2-isopropyl-4-(2,6-dinitro-4-methylphenoxy)anisole 
• 733802-66-9 C₁₆H₁₃Cl₄NO₄ 
• 733802-59-0 4-(2,6-dibromo-3-methyl-4-nitrophenoxy)-2-isopropylanisole 
• 733802-71-6 C₁₆H₁₄Cl₃NO₄ 
• 156740-82-8 3,5-dichloro-4-(3'-isopropyl-4'-methoxyphenoxy)-nitrobenzene 
• 525584-73-0 4-(2,6-dibromo-4-nitrophenoxy)-2-isopropylphenol 
• 355129-22-5 4-(4-amino-2,6-dibromophenoxy)-2-isopropylphenol 
• 355129-18-9 4-((3,5-dibromo-4-(4-hydroxy-3-isopropylphenoxy)phenyl)amino)-4-oxobutanoic acid 
• 169113-83-1 3,5-dibromo-4-(3-isopropyl-4-methoxyphenoxy)aniline 
• 355129-25-8 4-(4-amino-2,6-dichlorophenoxy)-2-isopropylphenol 
• 525575-58-0 5-bromo-1,3-dichloro-2-(3-isopropyl-4-methoxyphenoxy)benzene 

Relevant articles and documents

Substituted diaryl ether compounds as retinoic acid-related orphan Receptor-γt (RORγt) agonists

The discovery of a series of substituted diarylether compounds as retinoic acid related orphan receptor γt (RORγt) agonists is described. Compound 1 was identified from deck mining as a RORγt agonist. Hit-to-lead optimization led to the identification of

Para -Selective hydroxylation of alkyl aryl ethers

para-Selective hydroxylation of alkyl aryl ethers is established, which proceeds with a ruthenium(ii) catalyst, hypervalent iodine(iii) and trifluoroacetic anhydride via a radical mechanism. This protocol tolerates a wide scope of substrates and provides a facile and efficient method for preparing clinical drugs monobenzone and pramocaine on a gram scale.

Re2O7 catalyzed dienone-phenol rearrangement

The dienone-phenol rearrangement of 4,4-disubstituted cyclohexadienones catalyzed by Re2O7 has been described. Multi-substituted phenols can be efficiently obtained in good to excellent yields by employing this catalytic protocol.