1352304-55-2Relevant academic research and scientific papers
Direct Borylation of Tertiary Anilines via C-N Bond Activation
Cao, Zhi-Chao,Li, Xiao-Lei,Luo, Qin-Yu,Fang, Huayi,Shi, Zhang-Jie
, p. 1995 - 1998 (2018)
The first successful catalytic borylation of unactivated aromatic C-N bonds of tertiary anilines without the preactivation or any directing groups is demonstrated. The reactivity of both N,N-dialkylarylamines and N-arylpyrroles were investigated systematically, and the targeted products were furnished in moderate to good yields. The DFT calculation results indicated that the catalytic cycle is furnished via a five-membered cyclic transition-state due to the steric hindrance of the Ni/NHC catalytic system.
Nickel-catalyzed reductive and borylative cleavage of aromatic carbon-nitrogen bonds in N-aryl amides and carbamates
Tobisu, Mamoru,Nakamura, Keisuke,Chatani, Naoto
, p. 5587 - 5590 (2014/05/06)
The nickel-catalyzed reaction of N-aryl amides with hydroborane or diboron reagents resulted in the formation of the corresponding reduction or borylation products, respectively. Mechanistic studies revealed that these reactions proceeded via the activation of the C(aryl)-N bonds of simple, electronically neutral substrates and did not require the presence of an ortho directing group.
