1352310-60-1Relevant articles and documents
Organocatalytically enantioselective approach to polysubstituted tetrahydropyridines and piperidines
Yu, Fang,Zhang, Xiaojing,Jiang, Yongwen
, p. 1873 - 1879 (2012/07/13)
A convenient and highly enantioselective method for assembly of functionalized 1,2,3,4,5-pentasubstituted tetrahydropyridines and piperidines was developed. This method relies on preparing the required enantiopure cyclic semi-acetals via an organocatalyzed Michael addition/cyclization cascade reaction of aldehydes and α-keto-α,β-unsaturated esters, and subsequent reductive amination/condensation with primary amines. Copyright