1352404-20-6Relevant articles and documents
Synthesis of highly enantioenriched hydroxy- and dihydroxy-fatty esters: Substrate precursors for cytochrome P450BioI
Singh, Arti A.,Zulkifli, Siti N.A.,Meyns, Michaela,Hayes, Patricia Y.,De Voss, James J.
, p. 1709 - 1719 (2012/02/06)
A series of highly enantioenriched hydroxy- and dihydroxy-fatty esters were required as part of our ongoing investigation into cytochrome P450 BioI. This mediates the biosynthesis of pimelic acid via C-C bond cleavage of long chain fatty acids within Bacillus subtilis. Herein we report the synthesis of various stereoisomers of methyl 7-hydroxytetradecanoate, methyl 8-hydroxytetradecanoate, and methyl 7,8-dihydroxytetradecanoate in highly enantioenriched form, using a combination of asymmetric synthesis and a preparative enantioselective HPLC is reported.