1352415-46-3

Upstream product

• 445264-60-8 3-methoxy-5-pyridineboronic acid pinacol ester 
• 1352419-09-0 rac-5-(3-bromophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine trifluoroacetate 
• 2142-63-4 1-(3-Bromophenyl)ethanone 
• 953741-63-4 rac-2-amino-2-(3-bromo-phenyl)-propionitrile 
• 1262858-68-3 rac-5-(3-bromophenyl)-5-methylmorpholine-3-thione 
• 1266784-81-9 (RS)-3-(3-Bromo-phenyl)-5-methoxy-3-methyl-3,6-dihydro-2H [1,4]oxazine 
• 1262858-66-1 rac-N-[1-(3-bromophenyl)-2-hydroxy-1-methylethyl]-2-chloroacetamide 
• 850991-69-4 5-methoxy-3-pyridinylboronic acid 
• 1262858-69-4 rac-5-(3-bromophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine 
• 1352419-08-9 rac-5-[3-(5-methoxypyridin-3-yl)phenyl]-5-methylmorpholin-3-thione 
• 1352419-07-8 rac-5-[3-(5-methoxypyridin-3-yl)phenyl]-5-methylmorpholin-3-one 

Downstream Products

• 1352415-47-4 (R)-5-[3-(5-methoxypyridin-3-yl)phenyl]-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine 

Relevant academic research and scientific papers

1,4 OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS

The present invention provides 1,4 Oxazines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present

5,6-DIHYDRO-2H-[1,4]OXAZIN-3-YL-AMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)

The present invention relates to novel 5,6-dihydro-2H-[1,4]oxazin-3-ylamine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease and dementia associated with beta- amyloid.