1352449-41-2

Upstream product

• 86555-51-3 t-BOC-L-Alanine 2,2,2-Trichloroethyl Ester 
• 1352449-39-8 C₂₄H₃₅Cl₃N₄O₅*ClH 
• 1352449-37-6 C₁₄H₂₄Cl₃N₃O₄*ClH 
• 1352449-35-4 C₁₁H₁₉Cl₃N₂O₃*ClH 

Relevant academic research and scientific papers

The total synthesis and structure-activity relationships of a highly cytotoxic depsipeptide kulokekahilide-2 and its analogs

We successfully completed the total synthesis of kulokekahilide-2, a cytotoxic depsipeptide from the Cephalaspiedean mollusk Phillinopsis speciosa. We have revised the absolute stereochemistry of kulokekahilide-2 to 21-l-Ala, 24-d-MePhe, 37-l-Ile, 43-d-Ala, 15-d-Hica, and 5S,6S,7S-Dtda. We also investigated the cause of the mis-assignment of the configuration in the originally proposed kulokekahilide-2 and concluded that methanolysis using MeONa caused partial racemization, which led to the mis-assignment. The structure-activity relationships of kulokekahilide-2 and its analogs indicate the importance of an l-amino acid at position 21.