135245-97-5

Upstream product

• 1676-81-9 N-benzyloxycarbonyl-L-serine methyl ester 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 1145-80-8 N-(benzyloxycarbonyl)-L-serine 

Downstream Products

• 864973-92-2 (4S,5S)-5-Allyl-4-hydroxymethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 864973-94-4 (4S,5S)-5-Allyl-4-azidomethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 864973-93-3 (4S,5S)-4-Methanesulfonyloxymethyl-2,2-dimethyl-5-(2-oxo-ethyl)-oxazolidine-3-carboxylic acid benzyl ester 
• 864973-87-5 (4S,5S)-5-Allyl-4-methanesulfonyloxymethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 864973-95-5 (4S,5S)-2,2-Dimethyl-5-(2-oxo-ethyl)-4-[(2,2,2-trifluoro-acetylamino)-methyl]-oxazolidine-3-carboxylic acid benzyl ester 
• 864973-88-6 (4S,5S)-4-Methanesulfonyloxymethyl-5-((E)-3-methoxycarbonyl-allyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 864973-90-0 (4S,5S)-5-Allyl-2,2-dimethyl-4-[(2,2,2-trifluoro-acetylamino)-methyl]-oxazolidine-3-carboxylic acid benzyl ester 
• 864973-91-1 (4S,5S)-5-((E)-3-Methoxycarbonyl-allyl)-2,2-dimethyl-4-[(2,2,2-trifluoro-acetylamino)-methyl]-oxazolidine-3-carboxylic acid benzyl ester 
• 864973-85-3 [(1S,2S)-1-(tert-Butyl-diphenyl-silanyloxymethyl)-2-hydroxy-pent-4-enyl]-carbamic acid benzyl ester 
• 864973-86-4 (4S,5S)-5-Allyl-4-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 1621435-86-6 tert-butyl 2-((S)-1-amino-3-((tert-butyldiphenylsilyl)oxy)-1-oxopropan-2-yl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate 
• 1621435-85-5 tert-butyl 2-((S)-3-((tert-butyldiphenylsilyl)oxy)-1-methoxy-1-oxo-propan-2-yl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate 
• 1621435-84-4 tert-butyl 2-(((S)-3-((tert-butyldiphenylsilyl)oxy)-1-methoxy-1-oxopropan-2-yl)carbamoyl)-2-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 138312-57-9 1,2:3,4-Di-O-isopropylidene-6-(N-(benzyloxycarbonyl)amino)-6-deoxy-7-O-(tert-butyldiphenylsilyl)-L-glycero-α-D-galacto-heptopyranose 

Relevant academic research and scientific papers

Simple and Practical Real-Time Analysis of Solid-Phase Reactions by Thin-Layer Chromatography

Solid-phase synthesis is a practical approach for simplifying the time-consuming and routine purification steps in the preparation of numerous naturally occurring molecules; however, studying such reactions is difficult due to the lack of a convenient monitoring method. By using thin-layer chromatography in conjunction with a photolabile linker on a resin, we developed a convenient and simple method for monitoring solid-phase reactions in real time by thin-layer chromatography. This method provides a user-friendly protocol for examining reaction conditions for solid-state syntheses.

SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF

Disclosed are compounds having enhanced potency in the modulation of NMD A receptor activity. Such compounds are contemplated for use in the treatment of conditions such as depression and related disorders. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.

Protection of Hydroxy Groups by Silylation: Use in Peptide Synthesis and as Lipophilicity Modifiers for Peptides

A survey of a series of organosilyl derivatives of serine and tyrosine has shown that they have a satisfactory stability profile for use in peptide synthesis.Only when alkaline conditions were used did side-reactions appear.A range of stability profiles have been determined from a study of organosilyl derivatised dipetides under different conditions, giving t1/2 values for hydrolysis ranging from 41 to 465 min in acid conditions, yet giving long-term stability at pH-values near to neutrality.

SYNTHESIS OF THE HOMOCHIRAL "TRICYCLIC HEART" OF MANZAMINE A

An expedient and enantiospecific synthesis of a strategically functionalized tricyclic intermediate for the construction of manzamine A is described.