135247-46-0Relevant articles and documents
Characterization of steroidal glycosides from Tylophora sylvatica
Gnabre,Pinnas,Martin,Mizsak,Kloosterman,Baczynskyj,Nielsen,Bates,Hoffmann,Kane
, p. 3545 - 3554 (1991)
Two new steroidal glycosides (tylophoroside 1 and its monoacetate acetyltylophoroside 2) from Tylophora sylvatica (Asclepiadaceae), a medicinal plant from the Ivory Coast, were characterized, largely by 2-D NMR methods. 1, C48H72O22, was found to have three sugars units connected by a vinyl ether linkage to the 3-position of a steroidal aglycone (a new feature in a natural product). The aglycone part contains a novel lactone ring attached at C-13, formed in nature after opening of the D-ring at the 14-15 bond. 1 and 2 have cardiotonic activity, and the aglycone tylogenin 3 if more active than the widely used dexamethasone in anti-allergic assays.