1352564-02-3Relevant articles and documents
One-pot synthesis of ureas from Boc-protected amines
Spyropoulos, Constantinos,Kokotos, Christoforos G.
, p. 4477 - 4483 (2014/06/09)
A practical one-pot synthesis of ureas is described. Boc-protected amines can be transformed into nonsymmetrical and symmetrical disubstituted and trisubstituted ureas utilizing 2-chloropyridine and trifluoromethanesulfonyl anhydride for the in situ generation of an isocyanate, which reacts with an amine. A variety of amines can be employed successfully, leading to high yields of isolated ureas.
Hydantoin-free synthesis of peptide ester isocyanates, isothiocyanates, and dipeptidyl ureas: The application of zinc dust in a carbonylation procedure without base
Narendra,Vishwanatha,Sureshbabu, Vommina V.
, p. 3247 - 3254 (2011/11/30)
Non-Schotten-Baumann conditions are described for the hydantoin-free synthesis of peptide ester isocyanates using activated zinc dust as a non-basic HCl scavenger. Also, the procedure gives no N-acylated products in the case of the conversion of amino acid and peptide amides into isocyanates. Georg Thieme Verlag Stuttgart · New York.