1352574-75-4Relevant academic research and scientific papers
Synthesis and antibacterial activity of some novel N-substituted 3-[4-(1-alkyl/acyl/aroyl-1H-benzimidazol-2-yl)phenyl]acrylate derivatives
Chaudhari, Raju B.,Vaidya, Sanjay D.,Karale,Pawar,Rindhe, Sahebrao S.
, p. 1208 - 1215 (2011/10/13)
Synthesis of a series of novel 3-[4-(1-alkyl/acyl/aroyl-1H-benzimidazol-2- yl)phenyl]acrylate derivatives has been reported. These derivatives are prepared by condensation of o-phenyle-nediamine with 4-bromobenzoic acid to give 2-(4-bromophenyl)-1H-benzimidazole which undergoes Heck reaction with alkyl acrylates to give the above benzimidazole derivatives. Subsequent reactions of these compounds with different types of electrophiles afford a series of the corresponding 1N-substituted alkyl/acyl/-aroyl/sulfonyl derivatives. Furthermore, the antibacterial activities of these compounds have been checked against Staphylococcus aureus and Salmonella typhimurium bacterial strains but the results are found to be disappointing.
