1352638-51-7Relevant articles and documents
Nickel-catalyzed cycloaddition of aromatic (O-benzyl)ketoximes with alkynes to produce isoquinoline and isoquinoline N-oxide derivatives
Yoshida, Yuji,Kurahashi, Takuya,Matsubara, Seijiro
supporting information; experimental part, p. 1140 - 1142 (2011/11/06)
A nickel-catalyzed cycloaddition of aromatic (O-benzyl)-ketoximes with alkynes to afford 3,4-disubstituted isoquinoline derivatives has been developed. The reaction involves oxidative addition of N-O bond of O-benzylketoxime to Ni(0) and subsequent intermolecular C-H bond activation via elimination of benzyl alcohol. It was also found that ketoximes participate in the nickel-catalyzed reaction with alkynes to furnish isoquinoline N-oxide derivatives.